Lab Series Daily Moisture Defense Lotion SPF 15 white tube packaging
Basic protection for Aging
What Makes This Different

One of the earliest men's-specific SPF moisturizers backed by Estée Lauder's R&D, this formula uniquely combines saccharomyces lysate for post-UV DNA repair support with a triple chemical sunscreen system. The inclusion of creatine and acetyl carnitine — ingredients more commonly associated with sports nutrition — targets men's thicker, more metabolically active skin.

Lab Series

Lab Series Daily Moisture Defense Lotion SPF 15 Review

Men's Grooming Staple
spf moisturizer lotion clinical Paraben Free Not Cruelty Free

A legacy men's SPF moisturizer with a surprisingly thoughtful antioxidant formula, but the SPF 15 ceiling feels like a relic of a bygone era. Great texture and barrier support for daily desk-bound protection, but you'll want something stronger for anything beyond a commute.

$56.00
3.4 oz / 100 ml · other sizes available
4.2 ★★★★★
1,200 reviews
Launched 2007 All-year use PAO: 12 months
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Verdicts

How well it fits each concern

Verdict by concern tap a concern for the case

Basic protectionfor AgingBroad-spectrum with avobenzone at SPF 15: meets the FDA bar for the early-skin-aging claim (SPF 15+), below the SPF 30 dermatologists recommend for daily use.Moderate evidenceGentleNo reviews collected yet

The case for it

  1. Ascorbyl Tocopheryl Maleate has early or mechanistic evidence for this concern, not trial-backed standing.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries none of the triggers this concern is sensitive to.

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Basic protection” is the verdict on 175 of 45,024 concern verdicts across the catalog; rule P4 decided 107 of them. Unchanged since September 5, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
P4 — SPF 15–29 broad-spectrum is protection, not the recommended level; 'falls short' would misstate a regulator-recognised product. · the full register
Carrying active
Ascorbyl Tocopheryl Maleate
Standing
plausible — trials support it
Form
plausible — studied range 5%, from the trials on the row; needs leave-on contact; judge it after ~12 weeks
Tolerability
gentle
Row checked
against its sources on July 17, 2026 (evidence table ev-2026.09-r228)

The studies behind the evidence row

All aging products →
Basic protectionfor Sun DamageBroad-spectrum with avobenzone at SPF 15: meets the FDA bar for the early-skin-aging claim (SPF 15+), below the SPF 30 dermatologists recommend for daily use.Moderate evidenceGentleNo reviews collected yet

The case for it

  1. Avobenzone is a first-line active — approved, monograph-listed or named in current guidelines — for this concern.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries none of the triggers this concern is sensitive to.

Same rule for everyone. “Basic protection” is the verdict on 175 of 45,024 concern verdicts across the catalog; rule P4 decided 107 of them. Unchanged since September 5, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
P4 — SPF 15–29 broad-spectrum is protection, not the recommended level; 'falls short' would misstate a regulator-recognised product. · the full register
Carrying active
Avobenzone
Standing
first line — a regulator recognises it for this use; trials support it · per 21 CFR § 352.10 Sunscreen active ingredients (US FDA — 21 CFR Part 352 (Sunscreen Drug Products for Over-the-Counter Human Use), via Cornell Legal Information Institute; part heading marked [STAYED INDEFINITELY], effective date stayed at 66 FR 67485), opened September 1, 2026
Form
adequate (declared 2%) — studied range up to 3%, from the OTC monograph or label; needs leave-on contact
Tolerability
gentle
Row checked
against its sources on September 1, 2026 (evidence table ev-2026.09-r228)

The studies behind the evidence row

All sun damage products →
Promisingfor DullnessHyaluronic Acid has trial-level evidence for dullness but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.Moderate evidenceGentleNo reviews collected yet

The case for it

  1. Sodium Hyaluronate has trial-level evidence for this concern but no guideline or regulatory standing yet.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries none of the triggers this concern is sensitive to.

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Promising” is the verdict on 7,858 of 45,024 concern verdicts across the catalog; rule R9p decided 7,858 of them. Unchanged since September 5, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
R9p — 0.5.0: 'Unproven' beside three filled dots read as one question answered twice with opposite words (7,018 rows). The chip measures standing, the dots measure trial volume; where the row carries at least one RCT or a tier-2 source (moderate dots) and the active is present at a working level, the honest word is Promising. Unproven is reserved for plausible-standing rows with limited or weak evidence, or an under-dosed form. Same rank as Unproven — a bet either way; the dots order them. · the full register
Carrying active
Sodium Hyaluronate
Standing
plausible — trials support it
Form
plausible
Tolerability
gentle
Row checked
against its sources on July 17, 2026 (evidence table ev-2026.09-r228)

The studies behind the evidence row

All dullness products →
Supporting rolefor DrynessNothing here targets dryness directly; hydration with photoprotection is the recognised companion to treating it, and this lotion does that without known triggers.Not yet assessedGentleNo reviews collected yet

The case for it

  1. Avobenzone has no evidence row yet for this concern — it is in the research queue.
  2. The formula carries none of the triggers this concern is sensitive to.

What would change this: A researched evidence row for the lead active would replace this with a verdict.

Same rule for everyone. “Supporting role” is the verdict on 8,197 of 45,024 concern verdicts across the catalog; rule R8 decided 4,250 of them. Unchanged since September 5, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
R8 — The category's job (barrier care, humectant hydration, gentle cleansing, photoprotection) is the documented supportive role for this concern. This is the honest verdict for a moisturizer on an acne page. · the full register
Carrying active
Avobenzone
Standing
not assessed
Form
plausible (declared 2%)
Tolerability
gentle
All dryness products →

Does the jobDoes what a SPF moisturizer is for: UVA coverage, actually moisturizes. Not measured from the label: wearable all day.

A verdict is DermApproved’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.09-r228 · how we decide

Assessment

Pros & Cons

Pros

  • ✓ Lightweight, non-greasy texture absorbs in under a minute with no white cast
  • ✓ Fragrance-free formula avoids irritation and cologne conflicts
  • ✓ Thoughtful antioxidant complex with saccharomyces lysate for post-UV repair support
  • ✓ Phytosphingosine and acetyl glucosamine provide genuine barrier-repair benefits
  • ✓ Broad-spectrum UVA/UVB coverage from a well-tested chemical filter trio
  • ✓ Nearly four decades of Lab Series R&D into men's skin behind the formulation
  • ✓ Travel-friendly tube packaging in both 1.7 oz and 3.4 oz sizes

Cons

  • ✗ SPF 15 falls below the current dermatological recommendation of SPF 30 minimum
  • ✗ Premium price of $56 is hard to justify for modest sun protection
  • ✗ Contains octinoxate, which some users and reef-protection advocates prefer to avoid
  • ✗ Can feel slightly tacky in hot, humid conditions
  • ✗ Chamomilla extract may trigger reactions in rare Asteraceae-allergic individuals
Review

Full Review

Before men's skincare was a billion-dollar category, before every barber shop carried serums and every grooming influencer had an SPF sermon, there was Lab Series. Launched in 1987 under Estée Lauder's Aramis division, the brand was built on a genuinely radical premise for the time: men's skin is different, and it deserves products formulated for its specific physiology. The Daily Moisture Defense Lotion SPF 15 was one of the products that carried that mission — a single-step solution for guys who couldn't be bothered with a routine but needed to stop treating their face like an afterthought.

The formulation tells a story that's more interesting than the packaging suggests. Up front, you have a standard chemical sunscreen trio — avobenzone at 2%, octinoxate at 7.5%, and octisalate at 3% — covering the UVA and UVB spectrum. It's a well-tested combination that's been the backbone of countless sunscreens. But dig deeper into the inactive ingredients and there's a layer of thoughtfulness that separates this from a simple sunscreen-moisturizer hybrid.

Saccharomyces lysate extract, a yeast-derived ferment, sits surprisingly high on the ingredient list. This ingredient has been studied for its ability to support the skin's natural DNA repair mechanisms after UV exposure — essentially helping your skin clean up damage that gets past the sunscreen shield. Paired with ascorbyl tocopheryl maleate, a stabilized vitamin C and E ester, the formula creates a two-pronged environmental defense: filters block incoming UV, while antioxidants neutralize the free radicals generated by whatever gets through.

Then there are the unusual inclusions. Creatine and acetyl carnitine HCL — ingredients you'd more likely find in a gym supplement than a face cream — appear in the formula. Lab Series has long positioned these as energy-boosting ingredients for skin cells, a nod to their research into men's higher metabolic skin activity. Whether you buy the marketing narrative or not, these ingredients do have some evidence for supporting cellular energy metabolism.

Phytosphingosine and acetyl glucosamine form the barrier-repair backbone of the formula. Phytosphingosine is a ceramide precursor that supports the skin's natural lipid barrier, while acetyl glucosamine provides gentle exfoliation and helps maintain skin smoothness. Together with cholesterol and phospholipids further down the list, they create a miniature barrier-repair system layered into what looks like a straightforward SPF moisturizer.

The texture is genuinely one of this product's strongest selling points. It's a fluid, lightweight lotion that absorbs in under a minute without the greasy residue, white cast, or pilling that plague so many SPF products. For men who have been traumatized by thick, chalky sunscreens, this feels like nothing on the skin — which is exactly the point. Lab Series understood early on that the best SPF for men is one they'll actually use.

But here's where the honest assessment gets uncomfortable: SPF 15 simply isn't enough anymore. When this product was formulated, SPF 15 was considered the gold standard for daily protection. Dermatology has since moved the goalposts to SPF 30 minimum, and for good reason — most people apply only 25-50% of the recommended amount of sunscreen, meaning your real-world protection from an SPF 15 might be closer to SPF 5-8. For desk workers with minimal sun exposure, this provides a baseline layer of defense. For anyone spending more than twenty minutes outdoors, it's insufficient.

The price adds another layer of complexity. At $56 for 3.4 ounces, this sits firmly in the premium tier for what is effectively a lightweight moisturizer with low-level sun protection. The antioxidant complex and barrier-repair ingredients justify some of that premium over a basic drugstore SPF, but the value proposition would be significantly stronger if the protection level matched current standards.

The fragrance-free formula is a genuine positive. Many men's products lean heavily on masculine fragrances that can irritate or conflict with cologne, so Lab Series' restraint here is welcome. The inclusion of chamomilla recutita (chamomile) extract is worth noting for the small percentage of people with Asteraceae family allergies, but for the vast majority, it functions as a soothing anti-inflammatory.

As a daily moisturizer, this product delivers. Skin feels hydrated, smooth, and comfortable throughout the day without midday oil breakthrough or dryness. The lightweight texture layers well under other products if you choose to build a routine around it. The tube packaging is practical and hygienic, though unremarkable.

The Daily Moisture Defense Lotion SPF 15 is a product caught between eras. Its formulation philosophy — thoughtful, science-forward, barrier-supporting — was ahead of its time. Its SPF level was not behind the times when it launched, but the world caught up and passed it. Lab Series has since released the All-In-One Defense Lotion SPF 35 that addresses this gap, which says something about the brand's own acknowledgment of shifting standards. For the man whose sun exposure amounts to the walk from his car to his office, this remains a perfectly competent daily moisturizer with a smart supporting cast of ingredients. For anyone who takes their sun protection seriously — which should be everyone — the SPF ceiling is a dealbreaker that no amount of saccharomyces lysate can fix.

Formula

Key Ingredients

The hero actives that drive this product's performance.

IngredientFunctionEvidence
Avobenzone (2%) (2%) Provides broad-spectrum UVA protection in this triple-filter system, working alongside octinoxate and octisalate to cover the full UV spectrum while the antioxidant complex helps stabilize avobenzone against photodegradation. Regulator-approved for Sun Damage · emerging certainty
Saccharomyces Lysate Extract A yeast-derived ferment lysate that supports the skin's natural DNA repair mechanisms after UV exposure, complementing the SPF filters by addressing damage that gets past the sunscreen shield. Not yet assessed
Ascorbyl Tocopheryl Maleate A stabilized vitamin C and E ester that delivers antioxidant protection against environmental free radicals, reinforcing the UV defense system while helping to brighten and even skin tone over time. Limited for Aging
Sodium Hyaluronate The low-molecular-weight form of hyaluronic acid penetrates more effectively to hydrate skin from within, counteracting the drying effect that some chemical sunscreen filters can have on the skin. Plausible mechanism for Dullness
Acetyl Glucosamine A sugar derivative that promotes gentle exfoliation and supports barrier function, working synergistically with the phytosphingosine in this formula to maintain skin smoothness without irritation. Not yet assessed
Phytosphingosine A sphingoid base naturally found in the skin's barrier that supports ceramide synthesis and has antimicrobial properties, helping to reinforce the moisture barrier that daily UV exposure can compromise. Not yet assessed
Full INCI List

Active Ingredients: Avobenzone 2%, Octinoxate 7.5%, Octisalate 3%. Inactive Ingredients: Water, Butylene Glycol, Silica, Hydrogenated Polyisobutene, Neopentyl Glycol Diethylhexanoate, Cyclopentasiloxane, Pentylene Glycol, Hydrogenated Lecithin, Ethylbisiminomethylguaiacol Manganese Chloride, Saccharomyces Lysate Extract, Acetyl Carnitine HCL, Birch Bark Extract, Phytosphingosine, Creatine, Octyldodecyl Neopentanoate, Robusta Coffee Seed Extract, Astrocaryum Murumuru Seed Butter, Ascorbyl Tocopheryl Maleate, Acetyl Glucosamine, Linoleic Acid, Sodium Hyaluronate, Tocopheryl Acetate, Cetearyl Alcohol, Polyphosphorylcholine Glycol Acrylate, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Phospholipids, Ethylhexylglycerin, Isohexadecane, Cholesterol, Neopentyl Glycol Diisostearate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylic/Capric Triglyceride, Glycerin, Lecithin, Behenyl Alcohol, Rosemary Leaf Extract, Chamomilla Recutita, Ethylhexyl Stearate, Carbomer, Ethylhexyl Palmitate, Propylene Glycol Dicaprate, Cyclodextrin, Nordihydroguaiaretic Acid, Sodium DNA, Linolenic Acid, Triethanolamine, Sodium Hydroxide, Polysorbate 80, Hexylene Glycol, Disodium EDTA, Potassium Sorbate, Sodium Dehydroacetate, Chlorphenesin, Phenoxyethanol, Sorbic Acid

Safety & Formulation Facts
✗ Not Pregnancy Safe ✓ Fragrance Free✓ Alcohol Free✗ Oil Free✗ Silicone Free✓ Paraben Free✓ Sulfate Free✗ Cruelty Free✗ Vegan✗ Fungal Acne Safe
Potential Irritants
octinoxatetriethanolamine
Common Allergens
chamomilla recutita
Compatibility

Skin Match

Best For
Works For
Not Ideal For
Routine Step

moisturizer

Time of Day

AM

Layering Tips

Apply as the final step in your morning routine after cleanser and any serums. Use a nickel-sized amount for full face and neck coverage. No need for a separate sunscreen underneath, though SPF 15 may not be sufficient for extended outdoor exposure.

Results Timeline

Immediate lightweight hydration and sun protection from first use. Skin texture improvements and reduced dullness within 2-3 weeks of daily use. Cumulative anti-aging and environmental defense benefits build over 6-8 weeks.

Pairs Well With
vitamin C serumretinol (PM only)gentle cleanser
Planning a combo? Check it against what you already use
Sample AM Routine
  1. Gentle foaming cleanser
  2. Hydrating serum
  3. Lab Series Daily Moisture Defense Lotion SPF 15
Sample PM Routine
  1. Gentle foaming cleanser
  2. Retinol treatment
  3. Night moisturizer
Evidence

Science & Expert Perspective

The Science

The triple chemical sunscreen system in this formula — avobenzone (2%), octinoxate (7.5%), and octisalate (3%) — covers both UVA and UVB wavelengths. Avobenzone is the only FDA-approved chemical UVA filter and remains the gold standard for UVA protection, though it is inherently photounstable. The octisalate in this formula may serve a dual role as both a UVB filter and an avobenzone stabilizer, as studies have shown that certain salicylate esters can reduce avobenzone photodegradation.

The inclusion of saccharomyces lysate extract is one of the formula's more distinctive features. This yeast-derived ingredient gained attention in dermatological research for its potential to support nucleotide excision repair, the skin's primary mechanism for fixing UV-induced DNA damage. One trial published in the Journal of Investigative Dermatology (Yarosh et al., 2001) demonstrated that DNA repair enzymes delivered topically via liposomes could reduce the incidence of actinic keratoses and basal cell carcinomas in xeroderma pigmentosum patients. While saccharomyces lysate operates through a different mechanism, the principle of supporting post-UV DNA repair pathways is well-established.

Ascorbyl tocopheryl maleate represents a stabilized combination of vitamins C and E in a single molecule. The synergistic antioxidant relationship between vitamins C and E is well-documented — a landmark study by Lin et al. published in the Journal of Investigative Dermatology (2005) showed that combining vitamins C and E with ferulic acid provided superior photoprotection compared to individual vitamins alone. While this particular ester form hasn't been as extensively studied as pure L-ascorbic acid, its stability advantage means it's less likely to degrade in the tube before reaching your skin.

Phytosphingosine, a naturally occurring sphingoid base, has been shown to support ceramide synthesis in the stratum corneum and exhibits antimicrobial activity. A paper published in Experimental Dermatology (Pavicic et al., 2007) demonstrated that phytosphingosine-containing formulations improved skin barrier function and reduced transepidermal water loss.

References
  1. Topical DNA repair enzymes in xeroderma pigmentosum — Journal of Investigative Dermatology (2001)
  2. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. — Journal of Investigative Dermatology (2005)

Dermatologist Perspective

Dermatologists generally recommend SPF 30 or higher for daily use, which places this product below the current standard of care for sun protection. That said, clinicians acknowledge that any SPF is better than none, and for patients who resist sunscreen entirely, a lightweight SPF 15 moisturizer can serve as a gateway product. The barrier-repair ingredients — phytosphingosine, cholesterol, phospholipids — align with what dermatologists look for in a well-formulated moisturizer. The fragrance-free formula and absence of common sensitizers make it broadly tolerable, though the octinoxate content may be a consideration for dermatologists advising environmentally conscious patients or those with specific chemical filter sensitivities.

Guidance

Usage & Recommendations

How to Use

Apply a nickel-sized amount to clean, dry skin every morning as the final step in your skincare routine. Spread evenly across face and neck, allowing 30-60 seconds for absorption before applying any makeup or heading outdoors. Reapply every two hours if spending extended time in the sun — though for prolonged outdoor exposure, consider supplementing with a dedicated SPF 30+ sunscreen. Can be layered over serums or treatments applied beforehand.

Value Assessment

At $56 for 3.4 oz, this product occupies premium territory for what is essentially a lightweight SPF 15 moisturizer. The supporting cast of antioxidants, barrier-repair ingredients, and ferment extracts partially justifies the price, and Lab Series' decades of men's-specific R&D carries weight. A 1.7 oz travel size is also available but offers less per-ounce value. However, the SPF 15 limitation significantly undermines the value proposition — you're paying luxury prices for protection that falls below modern dermatological recommendations. Drugstore options at SPF 30+ exist for a fraction of the cost, though they typically lack this formula's sophisticated supporting ingredients.

Who Should Buy

Men looking for a fuss-free daily moisturizer with baseline sun protection who spend most of their day indoors. Ideal for the guy who wants anti-aging and hydration benefits in a single, lightweight step without dealing with the texture issues of heavier sunscreens.

Who Should Skip

Anyone who spends significant time outdoors or takes sun protection seriously — SPF 15 simply isn't enough. Also not ideal for those who prefer mineral sunscreens, are sensitive to chemical UV filters, or want cruelty-free certified products.

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Details

Product Details

Texture

Lightweight, fluid lotion that spreads easily and absorbs quickly without leaving a heavy or greasy residue

Scent

Fragrance-free with a very mild, neutral product scent

Packaging

White squeeze tube with color-coded labeling in the Lab Series system, practical and travel-friendly

Finish
non-greasylightweightnatural
What to Expect on First Use

Applies like a lightweight moisturizer with immediate hydration. No stinging, tingling, or adjustment period for most users. The lotion absorbs within 30-60 seconds, leaving skin feeling comfortable and lightly protected.

How Long It Lasts

Daily use makes one last about 3-4 months to the face

Period After Opening

12 months

Opened yours? Track the toss-by date
Best Season

All Year

Background

The Story Behind This Product

Lab Series pioneered the men's skincare category in 1987 when most brands didn't acknowledge that men needed skincare at all. The Daily Moisture Defense was designed as the gateway product — a single-step solution for men who wanted sun protection and anti-aging benefits without a multi-product routine.

About Lab Series Established Brand (5–20 years)

Lab Series launched in 1987 under Estée Lauder Companies as a pioneer in men's skincare, originally developed by the Aramis division. With nearly four decades of dedicated research into men's skin physiology, the brand has built a credible track record backed by the resources of one of the world's largest beauty conglomerates.

Brand founded: 1987 · Product launched: 2007
Myth vs. Reality

Common Myths

Myth

SPF 15 is enough for daily sun protection

Reality

Dermatologists now recommend SPF 30 or higher for daily use. SPF 15 blocks about 93% of UVB rays compared to 97% for SPF 30, and most people underapply, further reducing effective protection. This product works for incidental exposure but isn't sufficient for prolonged outdoor activity.

Myth

Men don't need moisturizer with SPF because their skin is tougher

Reality

Men's skin is thicker and produces more sebum, but it's equally vulnerable to UV-induced aging and damage. In fact, men statistically develop more skin cancers, partly because they're less likely to use sun protection consistently.

FAQ

Frequently Asked Questions

Is Lab Series Daily Moisture Defense Lotion SPF 15 enough sun protection?

SPF 15 provides adequate protection for brief incidental sun exposure like commuting or running errands. However, if you spend extended time outdoors, dermatologists recommend layering a dedicated SPF 30+ sunscreen over this moisturizer or choosing a higher-SPF product. This formula's triple-filter avobenzone system does cover both UVA and UVB, but the protection ceiling is limited.

Can women use Lab Series Daily Moisture Defense Lotion?

Absolutely. While Lab Series markets to men, the formulation itself contains no gender-specific ingredients. The lightweight, non-greasy texture and fragrance-free formula work well on any skin. The only consideration is whether SPF 15 meets your personal sun protection needs.

Does this product leave a white cast?

No. This formula uses chemical UV filters (avobenzone, octinoxate, octisalate) rather than mineral filters, so it absorbs into the skin without leaving a visible white residue. This makes it suitable for all skin tones.

Is Lab Series cruelty-free?

Lab Series is owned by Estée Lauder Companies, which sells in markets that require animal testing. The brand does not carry Leaping Bunny or PETA cruelty-free certifications.

Can I use this with retinol at night?

Yes — this is an AM-only product with SPF, making it an ideal daytime partner for a PM retinol routine. The phytosphingosine and acetyl glucosamine in this formula help support barrier repair, which complements the skin-turnover effects of nightly retinol use.

Reviews

What Reviewers Tend to Say

Recurring themes our editors read across retailer reviews of this product — summaries in our words, not quotations, and not a substitute for your own patch test.

Common Praise

Lightweight and non-greasy

Absorbs quickly without white cast

Good daily moisturizer for men

Pleasant texture under makeup or alone

Common Complaints

SPF 15 is too low for adequate sun protection

Expensive for the level of SPF provided

Contains octinoxate which some users prefer to avoid

Can feel slightly tacky in humid weather

Related Conditions
agingsun damagedullnessdryness
Related Ingredients
avobenzoneprobiotics prebioticshyaluronic acidphytosphingosineacetyl glucosamine