Niacinamide vs Vitamin C: You're Asking the Wrong Question
They brighten through completely different machinery — which is exactly why the 'pick one' framing is a trap.
It blurs the line between skincare and makeup — an essence that preps and primes while genuinely treating skin with niacinamide, ceramides, adenosine, and a fermented radiance complex. Rather than a silicone primer that just smooths and grips, it creates a dewy, lit-from-within base that doubles as a brightening, barrier-supporting skincare step, embodying the brand's 'InBetween' idea.
A genuinely clever skincare-makeup hybrid: a prep essence that smooths and illuminates the skin into a radiant base while actually treating it with niacinamide, ceramides, and adenosine. It makes foundation sit more evenly and gives a dewy, lit-from-within glow, doubling as real skincare in the final pre-makeup step. The alcohol and fragrance and its glow-not-matte finish are the main caveats.
This essence has a few years on the market and a moderate K-beauty review base, and its core actives — niacinamide, ceramides, and adenosine — are well-studied, but the fermented radiance complex has limited direct topical evidence and the product itself has not been independently clinically tested. The rating leans on the established science of its main actives and that review history, while the real-world glow contribution of the ferments carries more uncertainty.
The case for it
What would change this: A researched evidence row for the lead active would replace this with a verdict.
Same rule for everyone. “Supporting role” is the verdict on 8,197 of 45,024 concern verdicts across the catalog; rule R8 decided 4,250 of them. Unchanged since September 5, 2026, engine 5.1.1.
Brand or formulator? Disclose a concentration or correct a fact →
The case for it
What would change this: A declared concentration would move this to a firmer reading of the dose.
Same rule for everyone. “Promising” is the verdict on 7,858 of 45,024 concern verdicts across the catalog; rule R9p decided 7,858 of them. Unchanged since September 5, 2026, engine 5.1.1.
Brand or formulator? Disclose a concentration or correct a fact →
The studies behind the evidence row
The case for it
What would change this: A declared concentration would move this to a firmer reading of the dose.
Same rule for everyone. “Good choice” is the verdict on 9,564 of 45,024 concern verdicts across the catalog; rule R5 decided 9,072 of them. Unchanged since September 5, 2026, engine 5.1.1.
Brand or formulator? Disclose a concentration or correct a fact →
The studies behind the evidence row
Also listed for Dullness — the actives here (Niacinamide, Ceramides, Adenosine, Probiotics & Prebiotics) are in our research queue for that concern; there is no verdict until their evidence rows are written. That is a gap in our table, not a mark against the product.
Does the jobDoes what a toner is for: adds something real, not alcohol-driven. Not measured from the label: restores skin pH, plays well with what follows.
Where our review and the verdict differ. The review below was written on the formulation and the published trials; the verdicts above apply the stricter standing test in our methodology — an active earns a recommendation only with guideline or regulatory standing for the concern. Where the two disagree, the verdict is DermApproved’s position.
A verdict is DermApproved’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.09-r228 · how we decide
Most products know what they are. A serum treats; a primer preps. Blithe's InBetween Makeup Prep Essence deliberately refuses that tidiness, planting itself in the gap between your last skincare step and your first makeup one and trying to do both jobs at once. It's an ambitious premise — hybrid products often end up mediocre at everything — so the fair question is whether this essence actually treats skin while it primes, or just borrows the language of skincare to dress up a primer. The answer, encouragingly, is that the skincare here is real, which is what makes the hybrid worth taking seriously.
Look at what's doing the work and the dual identity holds up. High in the formula sits niacinamide, the multitasker that brightens, evens tone, regulates oil, and supports the barrier — and in a prep context, its oil-balancing and smoothing help foundation grip and last. Backing it is a skin-identical lipid trio of ceramide NP, cholesterol, and phytosphingosine that replenishes the barrier and creates the supple, even surface makeup wants to sit on, adding genuine moisture-retention value rather than the dehydrating tightness some primers leave. There's adenosine, a well-evidenced anti-aging active that smooths the look of fine lines so makeup settles more evenly over them — a real reason this suits mature skin especially. And a fermented radiance complex of yeast and lactobacillus ferments (potato, coix seed, soybean, rice, ginseng) supplies the brightening, antioxidant glow that defines the 'prep' effect. That's a legitimately well-chosen active stack; this isn't a silicone blur in disguise.
What it actually does on the skin matches the pitch. Patted on as the last step before foundation, it leaves the complexion smoother and visibly more luminous — lit-from-within rather than coated — and makeup applied over it tends to go on more evenly. The texture is a lightweight, slightly milky essence-lotion that sinks in fast to a soft, radiant, cushioned finish, quite different from the slick silicone feel of a conventional primer. It can also be worn alone for a no-makeup dewy glow, which is arguably one of its nicest uses. The honest framing is that it primes by improving the skin itself rather than by laying down a smoothing film, and that's both its charm and its limitation.
Because this is a glow primer, not a grip-and-mattify one, and that finish defines who it's for. Normal-to-dry skin will love the radiance; combination skin can use it strategically, helped by the niacinamide's oil control; but very oily skin chasing a matte, all-day long-wear base will likely find it too dewy. It's also not the right tool if you want the pore-blurring, foundation-extending performance of a dedicated silicone primer — it improves the canvas, but it won't fill texture the way a film-former does. Knowing which kind of 'prep' you want is the key to not being disappointed.
The other honest caveats are the formula's irritation flags. There's alcohol fairly high in the ingredient list, which contributes to the quick-setting, fresh feel but can be drying, and there's added fragrance. Most people tolerate both fine, and they're part of why the finish feels so clean and fast-drying, but for sensitive, dry, or reactive skin this combination warrants a patch test and may simply not suit. It's also not fungal-acne-safe given the esters and ferments. And the 1 oz size is modest for the price, which nudges the value from strong to merely fair.
The ferment radiance complex is the part most responsible for the 'glow' people notice, and it is worth understanding for what it is. The Saccharomyces and Lactobacillus filtrates of potato, coix seed, soybean, rice, and ginseng sit in the galactomyces-adjacent family of ferments that K-beauty has long associated with luminosity; their topical evidence is promising rather than proven, so the radiance they give is best read as a real but largely cosmetic sheen layered over the genuine, slower brightening from niacinamide. The alcohol, meanwhile, is doing a deliberate job — it speeds the set and gives that fresh, quick-drying finish that makes the essence pleasant to apply right before foundation — but it is also the ingredient most likely to bother dry or compromised skin, which is the trade you accept for the texture. For its intended user, that balance lands well; for a barrier-sensitive one, it is the reason to look elsewhere.
Weighing it up, the InBetween essence succeeds at the thing hybrids usually fail at: it genuinely does two jobs rather than faking one. You're paying a moderate K-beauty price for a prep step that brightens, hydrates, supports the barrier, and smooths fine lines while giving makeup a more radiant, even base — and from a cruelty-free brand. For normal-to-dry skin that wants glow, a treatment-grade primer, or simply a luminous final layer with or without makeup, it's a smart, likable product that earns its 'InBetween' name. The alcohol, fragrance, and dewy-only finish keep it from being universal, but within its lane it's a genuinely useful little bridge between skincare and makeup.
The hero actives that drive this product's performance.
| Ingredient | Function | Evidence |
|---|---|---|
| Niacinamide | Sitting high in the formula, niacinamide is the active that lets this prep essence double as skincare — brightening, evening tone, regulating oil, and reinforcing the barrier so makeup applies over a smoother, more radiant base. In a makeup-prep context, its oil-balancing and tone-evening work helps foundation sit and last better, making it the bridge between the product's skincare and primer roles. | Emerging for Hyperpigmentation |
| Ceramide NP & Barrier Lipids (Cholesterol, Phytosphingosine) | This skin-identical lipid trio — ceramide NP, cholesterol, and phytosphingosine — replenishes the barrier and smooths the skin's surface, creating the supple, even canvas that makeup grips to. Beyond priming, it adds genuine skincare value by supporting moisture retention, so the essence preps without the dehydrating feel some primers leave behind. | Not yet assessed |
| Adenosine | Adenosine brings a well-evidenced anti-aging note to the prep step, helping smooth the look of fine lines so makeup sits more evenly over them. Its inclusion is what nudges this beyond a simple primer into a treatment-prep hybrid, giving mature skin in particular a firmer, smoother base before foundation. | Limited for Aging |
| Fermented Radiance Complex (Saccharomyces, Lactobacillus Ferments) | A blend of yeast and lactobacillus ferments — potato, coix seed, soybean, rice, and ginseng — supplies the brightening, radiance-boosting glow that defines the 'prep' effect. These ferments add antioxidants and skin-conditioning amino acids that give skin a luminous, healthy sheen, the dewy lit-from-within base the essence is designed to create under makeup. | Not yet assessed |
Ingredient standings describe the active at treatment-level doses and vehicles; this product's own condition grades weigh its actual formula.
Water, Dipropylene Glycol, Alcohol, Niacinamide, Betaine, Glycerin, Polyglyceryl-10 Stearate, Glycereth-26, 1,2-Hexanediol, Polyurethane-15, Propanediol, Cetearyl Alcohol, Tromethamine, Fragrance, Carbomer, Hydroxyethylcellulose, Ceramide Np, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Triethylhexanoin, Adenosine, Squalane, Phospholipids, Hydrogenated Polydecene, Saccharomyces/Potato Extract Ferment Filtrate, Saccharomyces/Coix Lacryma-Jobi Ma-Yuen Seed Ferment Filtrate, Lactobacillus/Soybean Ferment Extract, Lactobacillus/Rice Ferment, Lactobacillus/Ginseng Root Ferment Filtrate, Disodium Edta, Cholesterol, Phytosphingosine, Solanum Lycopersicum (Tomato) Leaf Cell Culture Extract
treatment
AM
Use it as the last skincare step before makeup: after your moisturizer, pat a thin layer over the face and let it set for a minute to create a smooth, radiant base, then apply foundation. It can also be worn on its own for a dewy no-makeup glow. Fragrance- or alcohol-sensitive skin should patch test first.
Immediate radiance and a smoother makeup base on first use. Niacinamide's brightening and tone-evening benefits build over a few weeks of regular use, with adenosine's smoothing accruing over a longer horizon.
The InBetween essence is interesting precisely because its priming claims rest on active skincare ingredients with real evidence rather than on film-forming silicones. Niacinamide, placed high in the formula, has robust data for improving barrier function via increased ceramide synthesis, reducing transepidermal water loss, modulating sebum, and evening tone through inhibition of melanosome transfer — all of which plausibly contribute to a smoother, more even, longer-wearing makeup base. The barrier-lipid complex is mechanistically sound: ceramide NP, cholesterol, and phytosphingosine are physiological stratum corneum components, and supplying them supports lamellar barrier repair and surface smoothness, which is genuinely relevant to how makeup sits. Adenosine is a well-validated anti-aging active with cosmetic evidence for reducing the appearance of fine lines and improving firmness, contributing the treatment-prep angle. The fermented complex — Saccharomyces and Lactobacillus filtrates of potato, coix seed, soybean, rice, and ginseng — provides amino acids, antioxidants, and conditioning agents associated with a radiance or 'glow' effect; this is the galactomyces-adjacent ferment category, which has promising but limited rigorous topical evidence, so its contribution is best regarded as cosmetic luminosity rather than a proven treatment. The principal evidence-based cautions are the alcohol, present relatively high and capable of drying or irritating sensitive and compromised skin despite aiding fast set and finish, and the added fragrance, a recognized sensitizer. No independent clinical trial exists for this specific product; the assessment rests on the established evidence for niacinamide, ceramides, and adenosine alongside more limited ferment data.
Skin-health professionals tend to view 'treatment primers' favorably when, as here, the priming benefit is driven by evidence-based actives rather than purely cosmetic film-formers. Niacinamide, ceramides, and adenosine are all ingredients commonly endorsed for barrier support, tone, and fine-line smoothing, and a product delivering them in a pre-makeup step can offer genuine skincare value beyond appearance. Clinicians often note, however, that alcohol-forward formulas can compromise the barrier in dry, sensitive, or eczema-prone skin, and that fragrance is a frequent trigger of irritant or allergic contact dermatitis — so this essence is one they would suggest patch testing for reactive skin. A recurring clinical point is that a prep essence is a complement to, not a replacement for, a complete routine and daily sunscreen, and that radiance-focused, dewy formulations suit normal-to-dry skin better than oily skin seeking a matte, long-wearing base. For appropriate skin types, a niacinamide- and ceramide-containing prep step is generally regarded as a reasonable, low-risk addition.
Use it in the morning as the last step before makeup. After your usual skincare and sunscreen, pat a thin, even layer over the face and let it set for about a minute to create a smooth, luminous base, then apply foundation. For a no-makeup day, you can wear it alone over moisturizer for a dewy glow. It is a pre-makeup radiance step rather than a treatment serum, so a little goes a long way. Because it contains alcohol and fragrance, patch test on the inner arm first if your skin is sensitive, dry, or reactive, and don't rely on it as a substitute for your full skincare routine.
Value here is fair rather than outstanding, hinging on the small size. You are getting a genuinely dual-purpose product — a makeup-prep step that also treats skin with niacinamide, ceramides, adenosine, and a radiance-boosting ferment complex — from a cruelty-free brand at a moderate K-beauty price, which is reasonable for the active payload and the convenience of combining two steps. The 1 oz bottle is modest, though, so the per-use cost runs higher than the price tag suggests, and at daily morning use it lasts a couple of months. The honest discount is on scope: it is a glow primer, not a mattifying or pore-filling one, so anyone needing those specific makeup-performance traits would spend better on a dedicated primer. For someone who values the skincare-while-priming hybrid and wants radiance, the combined-step convenience justifies the price.
Reach for this if you have normal, dry, or combination skin and want a prep step that gives a dewy, lit-from-within base while genuinely treating skin with niacinamide, ceramides, and adenosine — it is ideal for glow-seekers, mature skin wanting smoother makeup application, and anyone who likes a skincare-makeup hybrid. It also works alone as a luminous no-makeup layer.
Skip it if you have very oily skin chasing a matte, long-wear base, or if you specifically want a pore-blurring silicone primer, since this is a glow-focused, non-mattifying formula. It is also the wrong choice for sensitive, dry, or reactive skin that reacts to alcohol or fragrance, and for fungal-acne routines.
Ready to try Blithe InBetween Makeup Prep Essence?
Buy at Amazon ♥A lightweight, slightly milky essence-lotion that spreads smoothly and sinks in quickly, leaving a soft, radiant, slightly cushioned finish rather than a silicone-slick primer feel.
A light added fragrance with a fresh, clean character, noticeable on application and fading within a few minutes.
A compact 1 oz bottle, typically with a pump for controlled dispensing — practical for a step applied right before makeup.
The immediate effect is a smoother, more luminous complexion — skin looks lit-from-within and feels primed rather than coated. There is a faint fresh scent and a light alcohol note as it sets. Most users find it comfortable, though the alcohol and fragrance make a patch test sensible for reactive skin. Makeup applied over it tends to go on more evenly.
2-3 months with daily morning use from the 1 oz bottle
All Year
Blithe launched the InBetween range to occupy the space between skincare and makeup, reflecting the K-beauty interest in glow and 'skin-first' makeup. The makeup-prep essence was designed for people who wanted their primer to also do skincare work, delivering radiance and treatment in the final step before foundation.
Blithe, the Korean brand known for its splash mask and pressed serum, created the InBetween line as skincare-makeup hybrids that sit between the two steps. This makeup-prep essence pairs skincare actives — niacinamide, ceramides, adenosine, and ferments — with a primer-like radiance role, and is a well-reviewed K-beauty product rather than a clinically studied one.
A makeup primer doesn't really do anything for your skin.
Many silicone primers are purely cosmetic, but this essence is built around active skincare ingredients — niacinamide, ceramides, and adenosine — that brighten, support the barrier, and smooth fine lines while they prep. It genuinely treats skin as it primes, which is the whole point of the hybrid format, though it is not a substitute for your full routine.
A dewy prep essence will make oily skin look greasy under makeup.
The radiant finish suits normal-to-dry skin best, but the niacinamide also helps regulate oil, so combination skin can use it strategically on drier areas. Very oily skin that wants a matte, long-wear base may indeed find it too dewy — this is a glow primer, not a mattifying one, and choosing it should match the finish you want.
It is a skincare-makeup hybrid — an essence applied as the last step before foundation that both primes the skin for a radiant, even base and treats it with active ingredients like niacinamide, ceramides, and adenosine. It creates a dewy, lit-from-within glow while supporting the skin barrier.
After your usual skincare and sunscreen, pat a thin layer over the face and let it set for about a minute to create a smooth, luminous base, then apply foundation. You can also wear it alone for a no-makeup dewy glow. It is a morning, pre-makeup step rather than a treatment serum.
Both — that is the point of the 'InBetween' concept. It primes skin for more even, longer-lasting makeup like a primer, but it does so with genuine skincare actives that brighten, hydrate, and smooth. It is not a silicone mattifying primer, so treat it as a glow-giving, treatment-style prep step.
It gives a dewy finish that suits normal-to-dry skin best, though its niacinamide helps with oil control, so combination skin can use it selectively. Very oily skin wanting a matte, long-wear base will likely find it too luminous — it is a radiance primer rather than a mattifying one.
Yes — it contains both alcohol, fairly high in the formula, and added fragrance. Most people tolerate them well, and they contribute to the quick-setting, fresh-feeling finish, but sensitive, dry, or reactive skin may find them drying or irritating, so patch testing is wise.
Recurring themes our editors read across retailer reviews of this product — summaries in our words, not quotations, and not a substitute for your own patch test.
Creates a smooth, radiant base for makeup
Doubles as skincare with real brightening actives
Gives a dewy, lit-from-within glow
Helps foundation apply and sit more evenly
Lightweight and absorbs without heaviness
Contains alcohol and fragrance that can irritate
Dewy finish may be too much for very oily skin
Not a long-wear mattifying primer
Small 1 oz size for the price
Not fungal-acne-safe