Advanced Clinicals Retinol Wrinkle Rewind Face Cream 2 fl oz glass jar with yellow label
Good choice for Aging
What Makes This Different

It is a retinol cream built as a moisturizer first: shea butter, rosehip oil and fatty alcohols carry a low, undisclosed dose of retinol with ferulic acid and its ethyl ester added to slow oxidation. That makes it a gentler on-ramp than the brand's retinol serum and one of the few sub-fifteen-dollar retinol creams with no fragrance, no alcohol and no dyes.

Advanced Clinicals

Advanced Clinicals Retinol Face Cream Review

Starter Retinol Night Cream
retinoid cream drugstore Paraben Free Cruelty Free Vegan

A thirteen-dollar retinol night cream that gets the basics right — fragrance-free, alcohol-free, buffered with shea and rosehip, stabilised with ferulic acid — and asks only that you accept a low, undisclosed dose in a jar. As a first retinol for dry or normal skin it is a sensible buy; as a wrinkle treatment it is the gentle end of the scale.

$12.99
2 fl oz / 59 ml
4.8 ★★★★★
24 reviews
Made in United States Launched 2022 Best for fall-winter PAO: 6 months
Buy at Amazon ♥

Two dozen reviews on the brand's own site is a very small pool for a product from a company whose best-sellers carry tens of thousands, and the cream was reformulated in late 2025, so part of even that feedback describes an earlier version. This assessment therefore rests on the ingredient list, the retinol literature and the tolerability record of the brand's other retinol products; it will firm up as reviews of the current jar accumulate.

Verdicts

How well it fits each concern

Verdict by concern tap a concern for the case

Good choicefor AgingRetinol is a trial-supported active for aging; this cream carries it, though the concentration is not declared.Moderate evidenceGentleNo reviews collected yet

The case for it

  1. Retinol has trial-supported standing for this concern.
  2. It is plausibly present at a working level, though the concentration is not declared.
  3. The formula carries none of the triggers this concern is sensitive to.

What would change this: A declared concentration would move this to a firmer reading of the dose.

Same rule for everyone. “Good choice” is the verdict on 9,564 of 45,024 concern verdicts across the catalog; rule R5 decided 9,072 of them. As of September 25, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
R5 — Trial-supported or guideline-supported active, adequately or plausibly dosed. · the full register
Carrying active
Retinol
Standing
supported — trials support it
Form
plausible — studied range 0.075–0.5%, from the trials on the row; needs leave-on contact; judge it after ~12 weeks
Tolerability
gentle
Row checked
against its sources on July 17, 2026 (evidence table ev-2026.09-r228)

The studies behind the evidence row

All aging products →
Good choicefor DrynessShea Butter is a reference standard by mechanism for dryness; this cream carries it high in the ingredient list.Moderate evidenceGentleNo reviews collected yet

The case for it

  1. Butyrospermum Parkii has trial-supported standing for this concern.
  2. It is present at an effective concentration, declared or high in the ingredient list.
  3. The formula carries none of the triggers this concern is sensitive to.

Same rule for everyone. “Good choice” is the verdict on 9,564 of 45,024 concern verdicts across the catalog; rule R5 decided 9,072 of them. As of September 25, 2026, engine 5.1.1.

Brand or formulator? Disclose a concentration or correct a fact →

Show the work
Rule
R5 — Trial-supported or guideline-supported active, adequately or plausibly dosed. · the full register
Carrying active
Butyrospermum Parkii
Standing
supported — its mechanism is established
Form
adequate — studied range 1–100%, from the trials on the row; needs leave-on contact
Tolerability
gentle
Row checked
against its sources on July 17, 2026 (evidence table ev-2026.09-r228)

The studies behind the evidence row

  • International Cosmetic Ingredient Dictionary and Handbook — declared function — Personal Care Products Council
  • Harry's Cosmeticology / Baran & Maibach Textbook of Cosmetic Dermatology — humectant, emollient and occlusive classification — standard reference text
All dryness products →

Also listed for Rough Texture and Dullness — the actives here (Shea Butter, Ferulic Acid, Rosehip Oil, Retinol) are in our research queue for those concerns; there is no verdict until their evidence rows are written. That is a gap in our table, not a mark against the product.

A verdict is DermApproved’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.09-r228 · how we decide

Assessment

Pros & Cons

Pros

  • ✓ Fragrance-free, alcohol-free and dye-free at a drugstore price
  • ✓ Shea butter and rosehip oil buffer the retinol for dry, mature skin
  • ✓ Ferulic acid and its ethyl ester slow retinol oxidation in the jar
  • ✓ Gentle enough for most beginners to use nightly within a few weeks
  • ✓ Smoother texture and fresher tone within four to six weeks
  • ✓ Works as a complete night moisturizer, no extra step needed
  • ✓ Green tea, turmeric and hops extracts add calming antioxidants

Cons

  • ✗ Retinol percentage is not disclosed and sits low in the list
  • ✗ Wide-mouth jar exposes the retinol to air and light with every use
  • ✗ Too rich for oily or acne-prone skin
  • ✗ Minimal effect on established wrinkles despite the label
  • ✗ Only two dozen product-level reviews and no Amazon listing of its own
  • ✗ Late-2025 reformulation makes older feedback unreliable
Review

Full Review

Advanced Clinicals is the company that taught Amazon shoppers to buy retinol in bulk. Its 16-ounce retinol body tub has been one of the platform's best-selling anti-aging products for a decade, on the strength of a big number on the label and a small one on the price tag, and its retinol face serum followed the same script. So it is a little surprising that the Retinol Face Cream, the line's 2-ounce nightly moisturizer, turns out to be the most careful retinoid the brand makes: a low dose, a buffered base, an antioxidant stabiliser, no fragrance, no alcohol. The label still says 'Wrinkle Rewind' in capitals, because that is who Advanced Clinicals is, but the formula underneath is modest in the best sense.

Start with where the retinol sits: seventeenth, after the rosehip oil and just before the hops extract. In a 39-ingredient cream that is a low cosmetic dose, and the brand does not disclose the percentage, so anyone hoping for the kind of numbers a dedicated retinol serum prints — 0.3, 0.5, 1 percent — is looking at the wrong product. What the position buys instead is tolerability. The base is a proper moisturizer: caprylic/capric triglyceride second, a fatty-alcohol structure, shea butter twelfth, rosehip oil sixteenth, sunflower oil further down. Green tea, turmeric and hops extracts add antioxidant and calming notes. Ferulic acid appears thirteenth and its ethyl ester at the very end, there to slow the oxidation that turns retinol brown and useless in an opened jar. A single signal peptide, palmitoyl tripeptide-37, is the 'proprietary peptide blend' of the marketing and is doing very little at its position. The late-2025 reformulation added the ferulic, the peptide and the rosehip; the earlier cream was plainer.

On the skin it is a pleasant night cream first and a retinoid second. The texture is medium-rich, pale yellow, cushioned by the shea and easily spread, and it settles to a soft satin finish that dry and normal skin will find comfortable through the night. There is no added fragrance; a faint earthy note from the rosehip and turmeric disappears on application. For the first week most people feel nothing except softer skin in the morning. In weeks two and three, those new to retinoids may find a little dryness or light flaking around the nose and mouth, which is the reassuring sign that the dose is real, and it passes as the skin adapts. By six weeks texture is smoother and tone a shade fresher. Fine lines soften a little over three months; deeper wrinkles do not move, and no honest reviewer of a cream at this dose should pretend otherwise.

The formulation choices make sense for its audience. This is a retinol for people who have never used one, or who tried a serum and peeled, or who want a moisturizer that does something extra without a second step. Oily skin will find the shea-and-oil base too rich, and should look at the brand's serum instead. Sensitive skin gets a friendlier list than most retinol products at any price, though retinol is retinol, and rosacea- or eczema-prone users should start slowly. The rose flower extract is the only ingredient a fragrance-allergic person might query; there is no parfum.

The jar is the real design flaw, and it is a flaw shared by the whole Advanced Clinicals range. Retinol oxidises on contact with air and light, and a wide-mouth glass jar opened every night is the least protective container it could be in. The ferulic acid and tocopherol are there to slow that decline, and they will, but the practical advice is to finish the jar in a couple of months rather than keep it for a year, and to store it closed in a dark cabinet. An opaque airless pump would be better and would cost more than the price allows.

The brand context cuts both ways. Advanced Clinicals has sold retinol products to a very large number of people for a long time without a reputation for trouble, which is a real, if unglamorous, form of evidence for tolerability. It has never published a clinical study or a concentration, and this particular cream has two dozen reviews on the brand's own site and no listing of its own on Amazon, so the assessment here leans on the ingredient list and on the retinol literature rather than on user feedback. The late-2025 reformulation also means that what little feedback exists may describe the older cream.

On value the arithmetic is simple. Thirteen dollars for two ounces of a fragrance-free, ferulic-stabilised retinol moisturizer is very cheap, and even at a pea-and-a-half a night the jar lasts around two months. What you give up for the price is a stated dose, a protective container and any evidence specific to the product. For a beginner that is a fair trade; for anyone who already tolerates a mid-strength retinol serum it is a step backward, and they should spend their money on something with a number on it.

So: buy it as a first retinol, or as a gentle nightly maintenance cream for dry or normal skin in the cooler months, use it at night with sunscreen the next morning, finish it in a season, and read 'Wrinkle Rewind' the way you would read any drugstore label — as an aspiration rather than a promise.

Formula

Key Ingredients

The hero actives that drive this product's performance.

IngredientFunctionEvidence
Retinol Seventeenth in the list, after the rosehip oil, which places this firmly at the low-dose end of over-the-counter retinol — enough to speed cell turnover gently over months in a cream meant for nightly use, not enough to peel or to match a dedicated retinol serum. Advanced Clinicals does not state the percentage. Emerging for Aging
Ferulic Acid + Ethyl Ferulate The cream's supporting antioxidant, present twice — as ferulic acid thirteenth in the list and as its ethyl ester at the very end — to slow the oxidation that degrades retinol in a jar and to add a little photoprotective backup to skin that a retinoid makes more sun-sensitive. Limited for Aging
Palmitoyl Tripeptide-37 The 'proprietary peptide blend' of the label, a single signal peptide twentieth in the list, intended to nudge collagen production alongside the retinol; at this position it is a supporting flourish and its contribution is modest. Limited for Aging
Rosa Canina (Rosehip) Fruit Oil A linoleic-rich seed oil listed just ahead of the retinol, adding fatty-acid nourishment and trace natural carotenoids; with the shea butter above it, it is what keeps a retinoid cream from drying the skin it is renewing. Not yet assessed
Butyrospermum Parkii (Shea) Butter Twelfth in the list, the occlusive emollient that turns this into a genuine night cream rather than a treatment — it buffers the retinol, seals moisture and is the reason the formula suits dry, mature skin better than oily skin. Established mechanism for Dryness · established mechanism
Full INCI List

Aqua/Water/Eau, Caprylic/Capric Triglyceride, Dimethicone, Glyceryl Stearate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Behenyl Alcohol, Cetyl Alcohol, Cetearyl Phosphate, Glycerin, Propanediol, Pyrus Malus (Apple) Fruit Extract, Butyrospermum Parkii (Shea) Butter, Ferulic Acid, Camellia Sinensis Leaf Extract, Rosa Damascena Flower Extract, Rosa Canina Fruit Oil, Retinol, Humulus Lupulus (Hops) Extract, Curcuma Longa (Turmeric) Root Extract, Palmitoyl Tripeptide-37, Oryza Sativa (Rice) Bran Extract, Helianthus Annuus (Sunflower) Extract, Helianthus Annuus (Sunflower) Seed Oil, Xanthan Gum, Tetrasodium Glutamate Diacetate, Copernicia Cerifera (Carnauba) Wax, Tocopherol, Silica Dimethyl Silylate, Caprylyl Glycol, Dimethicone Crosspolymer, Phenoxyethanol, Ethylhexylglycerin, Hexylene Glycol, Sodium Hydroxide, Polysorbate 20, Rosmarinus Officinalis (Rosemary) Leaf Extract, 1,2-Hexanediol, Disodium Cocoamphodiacetate, Ethyl Ferulate

Safety & Formulation Facts
✗ Not Pregnancy Safe ✓ Fragrance Free✓ Alcohol Free✗ Oil Free✗ Silicone Free✓ Paraben Free✓ Sulfate Free✓ Cruelty Free✓ Vegan✗ Fungal Acne Safe
Potential Irritants
RetinolRosa Damascena Flower Extract
Compatibility

Skin Match

Works For
Not Ideal For
Routine Step

moisturizer

Time of Day

PM

Layering Tips

Use it as the last step at night, on dry skin after any water-based serum; skip other retinoids and exfoliating acids on the same night, and keep vitamin C for the morning as the brand itself advises. Daily sunscreen is non-negotiable.

Results Timeline

Softer, better-moisturised skin from the first night; smoother texture and a fresher tone after 4-6 weeks; any visible softening of fine lines needs 12 weeks or more of nightly use, and deeper wrinkles will change little at this dose.

Pairs Well With
moisturizersunscreenserumeye-cream
Planning a combo? Check it against what you already use
Conflicts With
retinoidexfoliantbenzoyl-peroxidevitamin-c
See where it fits — layering order & night-splitting
Sample AM Routine
  1. Cleanser
  2. Vitamin C serum
  3. Moisturizer
  4. Sunscreen
Sample PM Routine
  1. Cleanser
  2. Hydrating serum
  3. Advanced Clinicals Retinol Face Cream
Evidence

Science & Expert Perspective

The Science

Retinol's credentials as a cosmetic anti-aging ingredient are not in dispute; the open questions for this cream are dose and stability. A 2017 study in the International Journal of Cosmetic Science examined the molecular basis of retinol's anti-ageing effects in naturally aged human skin in vivo, documenting increased epidermal thickness, stimulated collagen and elastin-related gene expression and improved dermal matrix after topical application — the mechanism by which any retinol cream, at sufficient dose, smooths texture and softens fine lines. A 2020 pilot study in the Journal of Cosmetic Dermatology compared two retinol concentrations in a randomised parallel trial and found both improved ageing-skin measures over the study period, with the higher concentration producing greater change and more irritation; Advanced Clinicals does not state its concentration, and retinol's position seventeenth in the list places it at the low end of that spectrum, where the expectation is gradual improvement in texture and tone rather than dramatic change.

The ferulic acid is more than decoration. A 2008 study in the Journal of the American Academy of Dermatology showed that ferulic acid stabilises topical vitamins C and E and doubles their photoprotective effect against ultraviolet-induced damage; retinol is a different molecule with the same vulnerability to oxidation, and the inclusion of ferulic acid and its ethyl ester alongside tocopherol in this cream is a sensible attempt to extend the active's life in a jar. It does not, however, solve the fundamental problem of a wide-mouth container, and it does not reduce the sun sensitivity a retinoid produces, so sunscreen remains essential.

The remaining actives — a single palmitoyl tripeptide, rosehip oil, green tea and turmeric extracts — have supporting evidence as antioxidants and emollients but are present at levels that make them contributors to tolerability rather than to efficacy. No product-specific testing has been published, and without a disclosed concentration the science supports the design of the cream as a gentle, well-buffered low-dose retinoid rather than any particular result.

Dermatologist Perspective

Seen from the clinic, this is the kind of product that gets a cautious nod for the patient who wants to start a retinoid but has been scared off by peeling: a low, buffered dose in a fragrance-free emollient base is exactly how tolerance is usually built before moving to something stronger. The absence of a stated concentration is the main frustration, because it makes it impossible to advise on where the cream sits relative to a 0.3 percent serum or to prescription tretinoin, and the jar packaging is a legitimate concern for potency over time. The standard counselling applies in full — nights only, sunscreen every morning, avoid in pregnancy, introduce two or three nights a week, and expect texture and tone to improve before lines do. Patients with rosacea, eczema or a damaged barrier should patch-test and go slowly regardless of the gentle base. For established rhytides the honest guidance is that a cosmetic retinol at this dose will not do what a prescription retinoid or a procedure can, and expectations should be set accordingly.

Guidance

Usage & Recommendations

How to Use

At night, after cleansing and allowing the skin to dry fully, take a pea-and-a-half of cream and smooth it over the face and neck, avoiding the eyelids and the corners of the nose and mouth. Start with two or three nights a week for the first fortnight and build to nightly as the skin allows; a little dryness or flaking around week two is normal and passes. No moisturizer is needed on top for dry or normal skin, though very dry skin can add a few drops of oil. Keep exfoliating acids and other retinoids off the same night, use vitamin C in the morning rather than layering it, and apply a broad-spectrum sunscreen every morning without exception. Store the jar closed in a dark, cool place and aim to finish it within a couple of months, since retinol in an opened jar loses potency.

Value Assessment

Thirteen dollars for a two-ounce jar of a fragrance-free, ferulic-stabilised retinol moisturizer is about as cheap as a credible retinoid gets, and the jar lasts roughly two months of nightly use, so the cost per month is trivial. What the price does not buy is a stated dose, an airless container or any product-specific evidence, and a buyer who already tolerates a mid-strength serum will find better value in something with a number on it. There is only one size. Advanced Clinicals' long record of selling retinol products without incident earns reasonable confidence in tolerability; the value is excellent for a beginner and merely adequate for anyone further along, and the late-2025 reformulation is a reason to buy the current jar rather than old stock.

Who Should Buy

Dry, normal or combination skin looking for a first retinol, or a gentle nightly maintenance cream in the cooler months, at a price that removes the fear of wasting money. It suits anyone who has peeled on a stronger serum and wants a buffered, fragrance-free cream that also serves as the night moisturizer.

Who Should Skip

Oily or acne-prone skin, which will find the shea-and-oil base too rich; anyone pregnant or breastfeeding; and users who already tolerate a mid-strength retinol serum and want a stated dose or visible results on deeper wrinkles. It is also the wrong choice for anyone who wants an airless, light-proof container for their retinoid.

Ready to try Advanced Clinicals Retinol Face Cream?

Buy at Amazon ♥

Or visit the Advanced Clinicals store on Amazon →

Details

Product Details

Texture

A pale yellow, medium-rich cream that spreads easily, feels cushioned from the shea and rosehip, and settles over a couple of minutes to a soft, satin finish with a faint sheen.

Scent

No added fragrance; a mild, slightly earthy note from the rosehip oil and turmeric extract that fades once the cream is on.

Packaging

A 2 fl oz glass jar with a white screw lid and a yellow 'Retinol Wrinkle Rewind Cream' label; sturdy and cheap, but a jar is the worst container for retinol, which oxidises with every opening, and there is no spatula.

Finish
satinvelvetynon-greasy
What to Expect on First Use

The first week feels like using a decent night cream — softer skin by morning, no tingle for most people. Those new to retinoids may notice mild dryness or a little flaking around the nose and mouth in weeks two and three, which is the dose being enough to register; it settles as the skin adjusts. Texture improvements show before anything happens to lines.

How Long It Lasts

About two months at a pea-and-a-half nightly on face and neck; the retinol also loses potency over months in an opened jar, so it is best finished rather than rationed.

Period After Opening

6 months

Opened yours? Track the toss-by date
Best Season

fall winter

Background

The Story Behind This Product

Advanced Clinicals' first retinol product was a 16 oz body tub that became one of Amazon's best-selling 'retinol' items on the strength of its size and price, followed by a face serum. This 2 oz face cream arrived in 2022 to give the line a proper nightly moisturizer with the same headline ingredient, and it was reformulated in late 2025 with ferulic acid, a peptide and rosehip oil replacing the earlier, plainer emollient base.

About Advanced Clinicals Established Brand (5–20 years)

Advanced Clinicals, founded in 2004 outside Chicago, is a mass-market value brand whose reach comes from Amazon, Walmart and its own store rather than from dermatology. It publishes no clinical testing and rarely states concentrations; its reputation rests on two decades of cheap, simple single-active products and very large review volumes on its best-sellers.

Brand founded: 2004 · Product launched: 2022
Myth vs. Reality

Common Myths

Myth

'Encapsulated retinol' or a 'wrinkle rewind' cream will erase established wrinkles.

Reality

At a dose this low — retinol is seventeenth in the list — the realistic outcome over three months is smoother texture, a fresher tone and slightly softer fine lines. Deep, static wrinkles respond to prescription retinoids or procedures, not to a cosmetic retinol moisturizer.

Myth

Because it is a gentle cream, it can be used in the morning under sunscreen.

Reality

Retinol degrades in light and makes skin more sun-sensitive, and ferulic acid does not change that. The brand's own directions say to use it at night and keep vitamin C for mornings; a jar of retinol cream applied by day mostly wastes the retinol.

FAQ

Frequently Asked Questions

How much retinol is in the Advanced Clinicals Retinol Face Cream?

The brand does not disclose a percentage. Retinol sits seventeenth in the ingredient list, after the rosehip oil, which points to a low cosmetic dose — gentle enough for nightly use by beginners, and a step down from dedicated retinol serums that state 0.3 to 1 percent.

Should I use the Advanced Clinicals Retinol Face Cream in the morning or at night?

At night only. Retinol breaks down in daylight and increases sun sensitivity, and Advanced Clinicals' own directions say to use vitamin C in the morning and this cream at night. A broad-spectrum sunscreen the following morning is essential while using any retinoid.

Can the Advanced Clinicals Retinol Face Cream be used with the brand's Retinol Face Serum?

It can, but there is little reason to. Both carry undisclosed retinol, and stacking them raises irritation without a clear gain. Beginners do better with the cream alone; anyone wanting a stronger effect should move to a serum with a stated percentage rather than layer two unknown doses.

Is the Advanced Clinicals Retinol Face Cream suitable for sensitive skin?

More so than most retinol products at the price: it is fragrance-free, alcohol-free and buffered with shea butter, rosehip oil and green tea extract. Truly reactive, rosacea-prone or eczema-prone skin should still patch-test and start two or three nights a week, since retinol itself can irritate regardless of the base.

Why does the Advanced Clinicals Retinol Face Cream contain ferulic acid?

Ferulic acid and its ethyl ester are antioxidants that slow the oxidation that degrades retinol, which matters in a jar that is opened nightly. They also add a small measure of antioxidant protection to skin that a retinoid makes more sun-sensitive; they do not replace sunscreen.

Can I use the Advanced Clinicals Retinol Face Cream while pregnant?

No. It contains retinol, and standard guidance is to avoid all topical retinoids during pregnancy and breastfeeding, even at low cosmetic doses. The brand's hyaluronic acid or collagen gel-creams are retinoid-free alternatives from the same range.

Reviews

What Reviewers Tend to Say

Recurring themes our editors read across retailer reviews of this product — summaries in our words, not quotations, and not a substitute for your own patch test.

Common Praise

Rich but not greasy on dry, mature skin

Gentle enough to use nightly without peeling

Skin feels smoother within a few weeks

Cheap way to start on retinol

Common Complaints

Retinol strength is not stated

Results on lines are slow and subtle

Jar packaging exposes the retinol to air

Too heavy for oily skin