Peptides: Signal, Carrier, Copper — Which Ones Actually Do Anything?
'Peptides' is one word standing in for a dozen unrelated molecules with wildly different evidence — most serums are hope in a bottle, but a few classes earn their place.
Not yet assessed for Aging
What Makes This Different
This formula combines two generations of Matrixyl peptides — Matrixyl 3000 and Matrixyl Synthe'6 — at a combined 10% concentration, which is among the highest available in any consumer skincare product. The Synthe'6 component is particularly notable: rather than stimulating collagen alone, it signals the production of six different matrix components simultaneously, offering a more comprehensive approach to structural skin repair than single-peptide products.
The Ordinary
The Ordinary Matrixyl 10% + HA Review
Budget Peptide Powerhouse
serum serum clinical Paraben Free Cruelty Free Vegan
Two generations of clinically studied peptides at 10% concentration, in a hydrating HA base, for 0.90. The math borders on absurd. Matrixyl 10% + HA delivers genuine collagen-stimulating signal peptides with zero irritation risk — making it one of the best anti-aging values available and one of the few options safe during pregnancy.
Made in Canada Launched 2016 All-year use PAO: 12 months
Run it through our tools Clashes with my routine? Pregnancy-safe? Find a cheaper dupe Patch-test it first
Verdicts All dullness products →All dehydration products →
How well it fits each concern
Verdict by concern tap a concern for the case
Promisingfor DullnessIn your profileYou chose · Glycerin has trial-level evidence for dullness but no guideline or regulatory standing yet — promising, short of a recommendation; the other actives here are not yet assessed for it.
The case for it
- Glycerin has trial-level evidence for this concern but no guideline or regulatory standing yet.
- It is present at an effective concentration, declared or high in the ingredient list.
- The formula carries none of the triggers this concern is sensitive to.
What would change this: Guideline or regulatory standing for the active on this concern would move this from a promising bet to a recommendation.
Same rule for everyone. “Promising” is the verdict on 7,858 of 45,024 concern verdicts across the catalog; rule R9p decided 7,858 of them. Unchanged since September 5, 2026, engine 5.1.1.
Brand or formulator? Disclose a concentration or correct a fact →
Show the work
- Rule
- R9p — 0.5.0: 'Unproven' beside three filled dots read as one question answered twice with opposite words (7,018 rows). The chip measures standing, the dots measure trial volume; where the row carries at least one RCT or a tier-2 source (moderate dots) and the active is present at a working level, the honest word is Promising. Unproven is reserved for plausible-standing rows with limited or weak evidence, or an under-dosed form. Same rank as Unproven — a bet either way; the dots order them. · the full register
- Carrying active
- Glycerin
- Standing
- plausible — trials support it
- Form
- adequate — studied range 2–20%, from the trials on the row; needs leave-on contact; judge it after ~1 weeks
- Tolerability
- gentle
- Row checked
- against its sources on July 17, 2026 (evidence table ev-2026.09-r228)
The studies behind the evidence row
- Harry's Cosmeticology / Baran & Maibach Textbook of Cosmetic Dermatology — humectant, emollient and occlusive classification — standard reference text
Good choicefor DehydrationIn your profileYou chose · Glycerin is a reference standard by mechanism for dehydration; this serum carries it high in the ingredient list.
The case for it
- Glycerin has trial-supported standing for this concern.
- It is present at an effective concentration, declared or high in the ingredient list.
- The formula carries none of the triggers this concern is sensitive to.
Same rule for everyone. “Good choice” is the verdict on 9,564 of 45,024 concern verdicts across the catalog; rule R5 decided 9,072 of them. Unchanged since September 5, 2026, engine 5.1.1.
Brand or formulator? Disclose a concentration or correct a fact →
Show the work
- Rule
- R5 — Trial-supported or guideline-supported active, adequately or plausibly dosed. · the full register
- Carrying active
- Glycerin
- Standing
- supported — its mechanism is established
- Form
- adequate — studied range 20%, from the trials on the row; needs leave-on contact; judge it after ~1 weeks
- Tolerability
- gentle
- Row checked
- against its sources on July 17, 2026 (evidence table ev-2026.09-r228)
The studies behind the evidence row
- USP glycerin monograph / Fluhr et al., glycerol and the skin (review) — glycerin is the reference humectant, drawing and holding water in the stratum corneum — reference work
Also listed for Aging and Rough Texture — the actives here (Glycerin, Hyaluronic Acid, Matrixyl Peptides) are in our research queue for those concerns; there is no verdict until their evidence rows are written. That is a gap in our table, not a mark against the product.
Where our review and the verdict differ. The review below was written on the formulation and the published trials; the verdicts above apply the stricter standing test in our methodology — an active earns a recommendation only with guideline or regulatory standing for the concern. Where the two disagree, the verdict is DermApproved’s position.
A verdict is DermApproved’s assessment of how well a product’s ingredients fit a concern — never a claim about what the product treats. Evidence dots and collected reviews sit beside it and are never blended in. Rules 0.5.1 · evidence table ev-2026.09-r228 · how we decide
Assessment
Pros & Cons
Pros
- ✓ Two generations of Matrixyl peptides at a generous 10% combined concentration
- ✓ Matrixyl Synthe'6 stimulates six matrix components simultaneously, not just collagen
- ✓ Zero irritation risk — suitable for the most sensitive skin types
- ✓ Pregnancy and breastfeeding safe — fills a gap left by retinoid restrictions
- ✓ Hyaluronic acid base provides immediate hydration alongside long-term peptide benefits
- ✓ Extraordinary value at $10.90 for a peptide concentration that competitors price at 0-150
- ✓ Fragrance-free, vegan, and compatible with retinoids in the same routine
Cons
- ✗ Slight tackiness on application from the HA base takes 2-3 minutes to resolve
- ✗ Results are gradual and subtle — requires 2-3 months for visible wrinkle improvement
- ✗ Cannot be combined with direct acids or L-ascorbic acid in the same routine
- ✗ Only available in 30 mL with no larger value size option
- ✗ Clinical studies for Matrixyl peptides are primarily manufacturer-funded rather than independently peer-reviewed
Review
Full Review
There is a version of skincare where anti-aging means retinoids, and retinoids mean redness, peeling, and a two-month adjustment period that tests your commitment to the cause. Then there is Matrixyl. No adjustment period. No irritation. No purging. No pregnancy restrictions. Just peptides, quietly doing their work beneath a layer of moisturizer while you go about your life entirely unbothered.
The Ordinary's Matrixyl 10% + HA has been part of the brand's lineup since its 2016 launch, and in many ways it embodies the DECIEM thesis more purely than any other product in the range. Matrixyl — a trade name developed by Sederma, the French cosmetic ingredient company now owned by BASF — had been a prestige ingredient for years, licensed to brands that sold peptide serums for 0, 20, sometimes 00. The Ordinary put it in a 0.90 bottle at 10% concentration and let the ingredient speak for itself.
The formula contains two Matrixyl generations. Matrixyl 3000 combines Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 — two peptides that work on opposite sides of the collagen equation. Tripeptide-1 is a matrikine, a signaling peptide that tells fibroblasts to produce new collagen as if they were repairing micro-damage. Tetrapeptide-7 reduces interleukin-6 secretion, an inflammatory cytokine that drives collagen degradation. One peptide pushes production up. The other pushes breakdown down. The combination, in manufacturer-funded clinical trials, reduced wrinkle area by 44% and wrinkle density by 37% over two months of twice-daily application.
Matrixyl Synthe'6, the second generation, goes broader. Palmitoyl Tripeptide-38 signals the production of six different extracellular matrix components simultaneously: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin 5. This is not just collagen stimulation — it is a comprehensive matrix repair signal. The skin's structural integrity depends on the interplay between all these components, and Synthe'6 addresses the scaffold as a system rather than targeting one protein in isolation.
The 10% concentration is worth appreciating in context. Many peptide serums list Matrixyl or its components on their INCI but at concentrations well below the levels used in clinical studies. At 10% of the total formula by weight, The Ordinary is delivering a genuinely generous dose. The peptides are dissolved in an aqueous base of glycerin and sodium hyaluronate, which provides immediate surface hydration and helps stabilize the peptides in a skin-compatible pH range of 5.0-6.0.
On the skin, this serum applies as a clear, slightly viscous liquid with a faint tackiness from the hyaluronic acid. It is not unpleasant, but if you have strong preferences about serum texture, you will notice it for the first two to three minutes before it absorbs. Once a moisturizer goes on top, the tackiness vanishes completely. There is no tingling, no warmth, no sensation at all — which is exactly what a peptide serum should feel like. Peptides work through cellular signaling, not through the kind of chemical activity that produces sensory feedback.
The timeline for results is where expectations need careful calibration. Peptides do not work like retinoids. There is no dramatic peeling phase followed by revealed baby-smooth skin. There is no purging period where things look worse before they look better. Instead, there is a slow, incremental improvement that builds over weeks and months. By week four, skin may feel slightly firmer and more hydrated — partly from the HA, partly from the early effects of increased collagen synthesis. By week eight to twelve, fine lines around the eyes and forehead begin to soften in a way that is easier to measure than to perceive in the mirror. By month three to six, the cumulative improvement becomes genuinely visible, particularly in before-and-after photographs.
This gradual nature is both the product's strength and its PR problem. Plenty of users have posted reviews saying some variation of "I used it for a month and I am not sure it did anything." Peptide results are not designed to be dramatic — they are designed to be sustainable. The collagen you build with consistent peptide use accumulates over time, and the anti-inflammatory effects of Tetrapeptide-7 help preserve what you build. It is investment-grade skincare: unglamorous in the short term, genuinely valuable over years.
The pregnancy-safe profile is a significant practical advantage. Retinoids — the other major category of collagen-stimulating actives — are contraindicated during pregnancy and breastfeeding. Matrixyl peptides carry no such restriction. For anyone who is pregnant, trying to conceive, or breastfeeding and wants to maintain an anti-aging routine, this product fills a gap that very few others can.
The conflict list is the main practical limitation. Peptides are hydrolyzed by low-pH environments, which means Matrixyl cannot be used in the same routine as glycolic acid, salicylic acid, L-ascorbic acid, or other direct acids. If your anti-aging strategy relies on vitamin C in the morning, you will need to use Matrixyl at night — or choose a vitamin C derivative that operates at a higher pH. For routines that already include retinoids and acids, fitting Matrixyl in requires some scheduling.
At $10.90 for a 30 mL bottle that lasts two to three months with twice-daily use, the annual cost of Matrixyl therapy is approximately 4-66. For context, department store peptide serums with lower Matrixyl concentrations regularly sell for 0-150 per bottle. The math is not subtle, and it is one of the most compelling arguments for The Ordinary's approach to skincare: that premium ingredients, at generous concentrations, do not require premium pricing.
Formula
Key Ingredients
The hero actives that drive this product's performance.
| Ingredient | Function | Evidence |
|---|---|---|
| Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7) (Within 10% total Matrixyl complex) | A dual-peptide system where Palmitoyl Tripeptide-1 signals fibroblasts to produce new collagen as if repairing micro-damage, while Palmitoyl Tetrapeptide-7 reduces IL-6 secretion to slow inflammation-driven collagen breakdown. Together they address both sides of the collagen equation — stimulating production and reducing degradation — in a synergistic approach that clinical testing has shown reduces wrinkle area by up to 44% over two months. | Not yet assessed |
| Matrixyl Synthe'6 (Palmitoyl Tripeptide-38) (Within 10% total Matrixyl complex) | A next-generation matrikine peptide that stimulates synthesis of six major extracellular matrix components simultaneously: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin 5. This broad matrix-repair signaling goes beyond simple collagen stimulation, addressing the full structural scaffold that keeps skin firm, elastic, and resilient. | Not yet assessed |
| Sodium Hyaluronate | Serves dual duty in this formula — providing surface hydration that plumps fine lines immediately while also acting as the aqueous delivery vehicle for the Matrixyl peptides. The hydrated environment helps maintain peptide stability and facilitates their penetration into the skin. | Established mechanism for Dehydration · established mechanism |
| Glycerin | The primary humectant that supports the hyaluronic acid in maintaining skin hydration. In a peptide serum, consistent moisture levels are essential for optimal peptide performance — dehydrated skin absorbs and utilizes topical peptides less efficiently. | Established mechanism for Dehydration · established mechanism |
Ingredient standings describe the active at treatment-level doses and vehicles; this product's own condition grades weigh its actual formula.
Full INCI List · pH 5.0-6.0
Aqua (Water), Glycerin, Butylene Glycol, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Hydroxypropyl Cyclodextrin, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Polyacrylate Crosspolymer-6, Trisodium Ethylenediamine Disuccinate, Carbomer, Polysorbate 20, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin
✓ Pregnancy Safe ✓ Fragrance Free✓ Alcohol Free✓ Oil Free✓ Silicone Free✓ Paraben Free✓ Sulfate Free✓ Cruelty Free✓ Vegan✗ Fungal Acne Safe
Compatibility
Skin Match
Best For
Works For
Routine Step
serum
Time of Day
AM & PM
Layering Tips
Apply after cleansing and toning, before heavier serums and moisturizer. Being water-based, it should go on before any oil-based products. Do not use in the same routine as direct acids or L-ascorbic acid — low pH destroys peptide bonds.
Results Timeline
Weeks 1-2: immediate hydrating effect from the HA base — skin feels plumper and smoother. Weeks 4-8: fine lines, particularly around the eyes and forehead, begin to soften as collagen synthesis increases. Weeks 8-16: cumulative improvements in firmness, elasticity, and wrinkle depth become more noticeable. Peptide results are gradual and build over months of consistent twice-daily use.
NiacinamideHyaluronic AcidRetinoids (in separate steps)MoisturizersSqualaneSunscreen
Planning a combo? Check it against what you already use Direct acids (AHA, BHA)L-Ascorbic Acid (pure)Resveratrol + Ferulic Acid
See where it fits — layering order & night-splitting
Sample AM Routine
- Gentle cleanser
- Toner
- The Ordinary Matrixyl 10% + HA
- Moisturizer
- Sunscreen SPF 30+
Sample PM Routine
- Gentle cleanser
- Toner
- The Ordinary Matrixyl 10% + HA
- Retinoid (if used)
- Moisturizer
Evidence
Science & Expert Perspective
The Science
The Matrixyl peptide complexes in this formula operate through matrikine signaling — the process by which peptide fragments of extracellular matrix proteins signal cells to synthesize new matrix components. This mechanism was first characterized for the original Matrixyl (palmitoyl pentapeptide-4, or pal-KTTKS), a fragment of type I collagen that Robinson et al. demonstrated could improve photoaged facial skin in a 2005 study published in the International Journal of Cosmetic Science.
Matrixyl 3000 advances this concept with two complementary peptides. Palmitoyl Tripeptide-1 activates collagen synthesis through TGF-beta signaling, while Palmitoyl Tetrapeptide-7 reduces IL-6 secretion in keratinocytes — an inflammatory mediator that accelerates matrix metalloproteinase (MMP) activity and collagen degradation. In Sederma's randomized, double-blind clinical study on 24 volunteers, twice-daily application of Matrixyl 3000 for 56 days produced a 44% reduction in deep wrinkle area, 37% reduction in wrinkle density, and measurable improvements in skin tone and elasticity.
Matrixyl Synthe'6 (Palmitoyl Tripeptide-38) represents a broader approach. Rather than targeting collagen alone, it signals the upregulation of six matrix components — collagen types I, III, and IV, fibronectin, laminin 5, and hyaluronic acid. This comprehensive matrix repair addresses the dermal-epidermal junction (collagen IV and laminin 5), the structural dermis (collagen I and III), the extracellular scaffolding (fibronectin), and the hydration matrix (hyaluronic acid) simultaneously. Raab et al. (Journal of Cosmetic Dermatology, 2020) demonstrated that a serum containing Palmitoyl Tripeptide-38 produced measurable improvements in wrinkle features after 56 days in a study of 35 women.
The palmitoyl conjugation of all three peptides is pharmacologically significant. The palmitic acid chain enhances lipophilicity, facilitating penetration through the lipid-rich stratum corneum that would otherwise be impermeable to free peptides. This delivery strategy — attaching a lipid anchor to a hydrophilic signaling peptide — has been validated across multiple cosmetic peptide studies.
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. — International Journal of Cosmetic Science (2005)
- A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception. — Journal of Cosmetic Dermatology (2020)
Dermatologist Perspective
Dermatologists view peptide serums as a useful complement to — rather than a replacement for — retinoids in anti-aging regimens. Dermatology guidance holds that Matrixyl peptides work through a different mechanism than retinoids (matrikine signaling vs. retinoid receptor activation), making them additive rather than redundant when used together. The pregnancy-safe profile makes Matrixyl one of the most commonly recommended anti-aging actives for pregnant and breastfeeding patients. Dermatologists caution that peptide results are more subtle and gradual than retinoid results, and set expectations accordingly — this is maintenance and prevention, not dramatic reversal. The 10% concentration in this product is considered generous by dermatological standards, and the conflict-free profile (except with acids) makes it easy to integrate into existing treatment plans.
Guidance
Usage & Recommendations
How to Use
Apply 4-5 drops to clean, dry skin morning and evening, after cleansing and toning but before heavier serums, oils, and moisturizer. Pat gently into the face, neck, and eye area. Allow 1-2 minutes for absorption before applying the next product. Can be used in the same routine as retinoids (apply Matrixyl first, retinoid second). Do not combine with AHA, BHA, L-ascorbic acid, or other low-pH products in the same routine — use them in separate AM/PM routines.
Value Assessment
At 0.90, The Ordinary Matrixyl 10% + HA is one of the most dramatic value propositions in the peptide serum category. Comparable products from established brands — using the same Matrixyl 3000 and Synthe'6 complexes, often at lower concentrations — retail for 0-150. A bottle lasts 2-3 months with twice-daily use, making the annual cost approximately 4-66. This pricing makes consistent, long-term peptide therapy financially accessible in a way that few other brands offer. The single 30 mL size means no volume discount for committed users, but the base price is low enough that this is a minor concern.
Who Should Buy
Anyone seeking a gentle, irritation-free approach to anti-aging that can be used alongside virtually any routine. Particularly valuable for pregnant and breastfeeding individuals who cannot use retinoids, for sensitive skin types who cannot tolerate retinol, and for budget-conscious consumers who want premium peptide technology without the 00+ price tag.
Who Should Skip
If you are looking for fast, dramatic anti-aging results, peptides will feel too slow and too subtle. Prescription tretinoin or high-strength retinol delivers more visible wrinkle reduction on a shorter timeline. Also not the right product if your primary concern is acne, hyperpigmentation, or exfoliation — Matrixyl addresses firmness and fine lines, not surface-level skin concerns.
Ready to try The Ordinary Matrixyl 10% + HA?
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Product Details
Texture
A clear, slightly viscous liquid serum that applies with a faintly tacky feel — attributable to the hyaluronic acid base. The tackiness resolves within 2-3 minutes and disappears entirely under moisturizer. Non-greasy and non-oily.
Scent
No discernible scent
Packaging
Frosted amber glass dropper bottle with white screw-top cap and glass pipette. Standard The Ordinary minimalist clinical design.
dewylightweightnon-greasy
What to Expect on First Use
On first use, the serum feels lightly hydrating with no tingling, stinging, or adjustment period. The slight tackiness on application may be noticeable if you are accustomed to fast-absorbing serums, but it dissipates quickly. There is no purging period with peptides — any breakouts that occur are likely a reaction to the base ingredients rather than a sign of accelerated turnover.
How Long It Lasts
2-3 months applied morning and night of 4-5 drops
Best Season
All Year
VeganCruelty-Free
Background
The Story Behind This Product
Matrixyl 10% + HA was one of approximately ten products in The Ordinary's debut lineup in 2016, and it represented the brand's ambition perfectly: a premium peptide complex that had previously been available only in 00+ serums, offered at 0.90. The Matrixyl name itself was developed by Sederma (now part of BASF), and the peptides have been licensed to hundreds of skincare brands — but few use them at this concentration, and fewer still price them this aggressively.
About The Ordinary Established Brand (5–20 years)
The Ordinary launched under DECIEM in 2016 and rapidly became the most disruptive force in skincare by offering clinical-grade actives at unprecedented price points. Now owned by Estée Lauder Companies, the brand has built nearly a decade of consumer trust through ingredient transparency and accessible pricing.
Brand founded: 2016 · Product launched: 2016
Myth vs. Reality
Common Myths
Myth
Peptides do not actually penetrate the skin and are therefore useless
Reality
While large proteins cannot penetrate the stratum corneum, the Matrixyl peptides in this formula are small, lipid-conjugated (palmitoylated) peptides specifically designed for skin penetration. The palmitoyl chain acts as a delivery vehicle, anchoring the peptide to skin lipids and facilitating transport. Clinical studies using these specific peptides have demonstrated measurable changes in wrinkle depth and collagen markers.
Myth
You can use peptides with acids in the same routine for maximum anti-aging
Reality
Low-pH environments cause peptide hydrolysis — literally breaking the bonds between amino acids that give peptides their function. Using Matrixyl with glycolic acid, L-ascorbic acid, or other direct acids in the same routine degrades the peptides before they can work. Separate them into AM and PM routines, or alternate days, for full benefit from both.
FAQ
Frequently Asked Questions
What does The Ordinary Matrixyl 10% + HA do?
This serum delivers two generations of Matrixyl peptides — Matrixyl 3000 and Matrixyl Synthe'6 — at a combined 10% concentration. These peptides signal your skin to produce collagen and five other structural matrix components (fibronectin, laminin, hyaluronic acid, and collagen types I, III, and IV). The hyaluronic acid base provides immediate hydration while the peptides work on long-term firmness and wrinkle reduction.
Is The Ordinary Matrixyl better than Buffet?
They serve different purposes. Matrixyl 10% + HA focuses entirely on two targeted peptide complexes at a high concentration, making it more potent for wrinkle-specific concerns. Buffet spreads its approach across multiple peptides, amino acids, and hyaluronic acid forms for broader anti-aging. Choose Matrixyl if your primary concern is fine lines and firmness; choose Buffet if you want a more generalized multi-peptide treatment.
Can I use Matrixyl 10% + HA with retinol?
Yes, but apply them in the correct order. Use Matrixyl first (water-based) followed by retinol. Both can be used in the PM routine. However, do not use Matrixyl with direct acids or L-ascorbic acid — the low pH environment destroys the peptide bonds.
Is The Ordinary Matrixyl 10% + HA safe during pregnancy?
Yes. Peptides are pregnancy-safe — they are small amino acid chains that do not carry the teratogenic risks associated with retinoids. This makes Matrixyl 10% + HA one of the best anti-aging options for pregnant and breastfeeding individuals who need to avoid retinol and retinoids.
How long does it take to see results from Matrixyl?
Peptide results are gradual. You may notice immediate hydration and plumping from the hyaluronic acid base, but the collagen-stimulating effects of the Matrixyl peptides typically become visible at 4-8 weeks of consistent twice-daily use. Maximum benefits develop over 3-6 months. Before-and-after photos are helpful for tracking subtle changes you might otherwise miss.
Why can't I use Matrixyl with vitamin C?
Pure L-ascorbic acid operates at pH 2.5-3.5, while Matrixyl peptides are formulated at pH 5.0-6.0. The acidic environment causes peptide hydrolysis — breaking the amino acid bonds that give the peptides their function. Use Matrixyl in one routine (e.g., AM) and vitamin C in the other (e.g., PM), or use a vitamin C derivative (like ascorbyl glucoside) which operates at a higher, peptide-compatible pH.
Reviews
What Reviewers Tend to Say
Recurring themes our editors read across retailer reviews of this product — summaries in our words, not quotations, and not a substitute for your own patch test.
Exceptional value for a 10% peptide serum — comparable products cost 0-150
Noticeable softening of fine lines around eyes and forehead within 4-8 weeks
Lightweight texture layers easily under other products without pilling
Extremely gentle — suitable for sensitive skin and pregnancy-safe
Hydrating HA base provides immediate plumping while peptides work long-term
Slight tackiness on application that takes a few minutes to resolve
Results are gradual and subtle — difficult to perceive without before/after photos
Some users report small whiteheads, possibly from butylene glycol
Only available in 30 mL with no larger value size
Cannot be combined with acids or vitamin C in the same routine
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