The active ingredients, and the concentrations used are the key markers of effective acne treatments. Skin irritation is another factor that is looked at. It is important for users to understand, however, that acne treatment takes time and therefore patience. Acne treatments take up to 6 months to see noticeable improvement, and many actives that are effective, unfortunately irritate the skin, especially at the start of treatment. With proper expectation and patience, however, the vast majority of acne will improve significantly with acne cleansers.